This research could show first documented case of acetaminophen production from plastic waste using E coli bacteria.

Researchers at Edinburgh University have succeeded in changing plastic waste into acetaminophen using natural properties of common bacterum Escherichia Coli Ecoli.

This breakthrough shows a milestone with potential to drive more methods of drug production and at same time contribute to decrease of plastic poluttion worldwide.

The study led by Stephen Wallace opened that E coli cells contain phosphate an organic compound capable of catalyzing a chemical reaction famous as Loseen rearrangement.

Acetaminophen tablet

This process consist the rearrangement of atome of hydroxamate ester molecule to shape a new structure called isocyanate a chemical intermediat that when reacted with water produces primary amines.

These substances are essential in biological method and in drug synthesis.

Using synthetic biology the scientist manipulated the bacteria to redirect internal chemistry and transform a PET derived molecule famous as terephthalic acid into active ingredient in acetaminophen.

They used fermentation method similar to that used in brewing beer to accelerate the conversion of industrial PET waste into drug obtaining results in less than 24 hours.

According to findings almost 90 percent of final product corresponded to acetaminophen.

This chat was done at room temperature and with virtually no carbon emission suggesting that drug can produced in more enviromentally friendly way.

Acetaminophen tablet

Wallace added that what was stunnign the method was that Lossen rearrangement happened naturally within living bacteria without need for laboratory catalysts.

They took advantage of microbia cells own capabilities to trigger desire reaction.

The funny thing is that we did not have to teach bacteria how to do reaction.

The trick was realize that had tools and we just had to guide them.

“We used synthetic biology to build new metabolic pathways within bacteria that guide their chemistry toward producing compoud we desired. In this case a drug”

Drug Production

The work published in Journal Nature could be first documented case of acetaminophen production from plastic waste using E coli..

The authors focus studies will necessary to gain industrial scale production.

In addition they caution that safety and efficacy of resulting drug in humans have to be evaluated so future research will be requied.

The sceintists stresses that results open up new possibilities for addressing problem of plastic waste and decreasing greenhouse gas emissions linked with drug manufacturing.

Acetaminophen tablet

Men with attention deficit hyperactivity disorder are being advise to contact their physician as Australia drug regulator warned a common medication used to treat the condition may be in short supply for rest of year.

ADHF drug shortages have been an ongoing problem in Australia for number of months.

Prof Dave Coghill Chair of Development Mental Health at University of Melbourne is warning public who with live with ADHD not to panic.

ADHD shortage

ADHD medication are experiencing a shortage.

Methylphenidate famous by its brand name as Ritalin, Ritalin LA and Concerta is in short supply in Australia due to manufacturing problems according to notice from Therapeutic Goods Administration on Wednesday which advise public to speak to pharmacist to assit source their prescription.

ADHD is neuro development disorder that affects how the brain develps processess and handles information about one in 20 Australians have it.

“People who live with ADHD have problems in three main areas which is difficulty with attention focus and planning “Coghill said.

“They often have problems with overactivity and restlessness and they often have impulsivity or impulsiveness”

Coghill added medication shortages can be challenging.

“We have now got good evidence to show that ADHD medications not only assist you concentrate and focus but assist you to stop and think before you act” Coghill said.

He said methylphenidate  is one of four medications used to treat ADHD and even within class of drug there is not complete shortage but shortage of brands at some doses.

ADHD shortage

“The problem we have is ones that are in shortage are changing constantly so it is very difficult to predict from one week to next which medications are going to be available” Coghill said adding people who live with ADHA should speak with doctor to work out good medication.

Tens of millions have place trust in Guardian fearless journalism since we started publishing 200 years ago turning to us in moments of crisis solidarity and hope.

Over 1.5 million supporters from 180 countries now power us financially keeping us open to all independent.

We provide all this for free for everyone to read.

We do this we believe in information equality.

Great numbers of people can keep track of global events shaping our world.

The Guardian has no shareholders and no bilionaire owner. The determination and passion to deliver high impact global reporting always free from commercial or influence.

So they do not make people feel better they assist people live safer more productive lives and ADHD medication are key to assisting people manage those symptoms.

A  massive increase in demand globally for ADHD drugs restrictions placedon manufacture of one of ingredients by US Drug Enforcement Agency hads led to shortages. Coghill said.

ADHD shortage

The TGA has covened a medicine shortage action group with health professional and peak body groups to assist manage ongoing shortage.

The Ozempic boom has view a drug used to treat diabetes and manage obesity in adults changes into miracle weight loss jab that coveted by anyone with few extra kilos to shed.

Ozempic and other medications such as Wegovy and Mounjaro are various brand names  for the drug semaglutide that mimci the actions of GLP-1 a hormone in brain that regulates appetite and felling of fulness.

Weekly doses of blockbuster weight loss medicines can assist people shed 15 to 20 per cent of their body weight on average.

It can also pile on years and make you look older than you are expets say.

Ozempic

Tooth decay

The latest side effect linked to use skinny jabs is tooth decay with experts noting a rise in number of patients complaining of Ozempic teeth.

“While there is no direct scientific evidence yet in clinical setting semaglutide drugs like Ozempic are starting to show correlation with damaged teeth.

Dr Sandip Sachar a dentis told The Standard.

The second reason is linked to acid reflux a common side effect these jabs.

An increase in amount of acid can erod your teeth.

Dr Daniel Atkinson told media.

First GLP-1 recepto agonists like Ozempic can lead to less saliva being produce and consequently hinder mouth self cleansing abilities.

Ozempic appetite suppression qualities can make it hard for body to get nutrients it requires to maintain healthy teeth.

Folds at the corner of the mouth

Dr Green told media that Ozempic mouth is something she is watching among many of clients taking blockbuster weight loss medication.

She said “Many users of Ozempic who I know report noticeable volume defeat in face which can result in formation of fine lines wrinkles jowls around the mouth,

Dr Gree noted appearance of aged mouth is apparent on people who swiftly lose weight from higher doses of GLP-1 drug.

The condition is considered part of broader phenomenon dubbed Ozempic face where rapid weigh losss causes sagging in cheeks and around mouth.

It is characterised by deep folds at corners of mouth increased vertical wrinkles on lips sagging skin around borders of lips and drooping skin around chin.

Dr Green notice number of celebrities suffering from Ozempic mouth as result of taking weight loss drugs with some of her standout examples being Sharon Osbourne Rebel Wilson and Whoopi Goldberg.

Ozempic

Lips get bigger

The most symptoms of condition consist of drooping around the cheeks sunken eyes and increased number of wrinkles plumper more pronounced pout can happen in people who have injectable fillers.

The expert who runs Grey Door Aesthetics in Hove said Losing weight at the Phenomenal rate Ozempic permits will lose the fat all over body including face but overfilled lips will not shrink.

“This is hugely ageing and obvious what procedutes have been carried out”

‘Any filler wont have support structure of skin.The filler will stay and lips stay big or biggert with skin laxity disapearing the client may feel need to plump with filler”

Cheeks sag

When you lose weight lover extended periods of time it allows the skin to contract and shrink with body but drugs like Ozempic accelerate the method.

While the weigh loss decrease facial or subcutaneous fat as well as making the body leaner.

This lead to cheeks that sag or droop and one of main characteristics of Ozempic face.

By depleting the subcultaneous fat the skin appears thinner with more wrinklinhg and often lipstick lines”

Eyes sink

Analyst said how Ozempic can make your eyes look more sunken as result of weight decrease with people reporting anywhere.

US based plastic surgeon pointed out a hollowing under eyes and move wrinkles and fine line around them as weight loss drug starts to show results.

More visible wrinkles

People using skinny jabs like Ozempic might notice mega number of wrinkles all over visage consisting on forehead as these miracle weight loss treatments cause loss of volume in face.

According to Dr Michele Green this volume loss can worsen the appearance of existing fine lines wrinkles and skin laxity and therefore contribute to more aged look with continued use.

Ozempic