The 49ers have not made selection in top 15 since 2021 when San Francisco drafted quarterback Trey Lance at No 3 overall after historic trade to move up from No 12 spot.

During coach Kyle Shanahan and general manager John Lynch tenure with 49ers San Francisco has made top 15 selection five times.

Following San Francisco 35-10 defeat to Buffalo Bills on Sunday at Highmark Stadium the 49ers are in position for top 15 selection current sitting in No 14 spot in 2025 NFL Draft order.

During coach Kyle Shanahan and general manager John Lynch tenure with 49ers.

San Francisco has made top 15 selection five time.

• Quarterback Trey Lance No 3 overall 2021
• Defensive tackle Javon Kinlaw No 14 overall 2020
• Defensive end Nick Bosa No 2 overall 2019
• Offensive tackle Mike McGlinchey No 9 overall 2018
• Defensive tackle Solomon Thomas No 3 overall 2017

With five matches remaining in 2024 NFL season against Chicago Bears, Los Angeles Rams, Detroit Lions, Arizona Cardinals, San Francisco has uphill fight to safe a playoff spot or even winning record.

San Francisco appears to have added multiple makers with few of its 2024 draft pick and opportunity to retool an aging roster by adding impact player near top of first round.

Here is how the 2025 draft order looks

• Pittsburgh Steelers 9-3
• Green Bay Packers 9-3
• Minnesota Vikings 10-2
• Philadelphia Eagles 10-2
• Buffalo Bills 10-2
• Kansas City Chiefs 11-1
• Detroit Lions 11-1
• Jacksonville Jaguars 2-10
• Las Vegas Raiders 2-10
• New York Giants 2-10
• New England Patriots 3-10
• Carolina Panthers 3-9
• New York Jets 3-9
• Cleveland Browns 3-8
• Tennessee Titans 3-9
• New Orleans Saints 4-8
• Cincinnati Bengals 4-8
• Chicago Bears 4-8
• Miami Dolphins 5-7
• Dallas Cowboys 5-7
• Tampa Bay Buccaneers 6-6
• Indianapolis Colts 6-7
• San Francisco 49ers 5-7
• Los Angeles Rams 6-6
• Arizona Cardinals 6-6
• Atlanta Falcons 6-6
• Denver Broncos 7-5
• Seattle Seahawks 7-5
• Washington Commanders 8-5
• Houston Texans 8-5
• Baltimore Ravens 8-5
• Los Angeles Chargers 8-4
• Pittsburgh Steelers 9-3

San Francisco 49ers running back Christian McCaffrey suffered what is believed to be injury to posterior crucial ligament in his right knee Sunday night leaving the rest of season in difficulty according to coach kyle Shanahan,

McCaffrey is slated to undergo testing Monday that will decide extent of injury and he can play in any of San Francisco five games.

For the first quarter plus against the Bills McCaffrey looked balanced for breakthrough night has been seeking since his comeback from Achilles injury.

Momentum came to screeching halt with 11:23 to go in second quarter when McCaffrey took pitch to right.

He planted his feet to turn upfield he instead opted to slide down without contact.

McCaffrey latest injury appeared to happen about 95 seconds before the play where he gave himself up. With 12:58 left in second quarter McCaffrey burst up middle for 18 yard gain.

George Kittle said

“Its not a great feeling but i mean its football”

“People go down and we have had season where plenty of people have gone down and you need someone to step up and that what we need. We continually need guys  to step up whether it starters and players that we have are already doing it or new guys who are getting into rotation.”

McCaffrey had been working back into form over last three weeks and said this week that he felt a breakout game was close.

Brock Purdy said

“We all saw what he was doing and he was on fire”

“He looked great. Hitting the holes hard and bouncing off guys and making some real explosive plays and that huge. He is one of best running backs in league and you lose him like that I think it takes away sort of how we do some things within offense it sucks”.

As he did for first pair months of season Jordan Mason filled in for McCaffrey while he was out.

Mason finished with 13 carries for 78 yards and rookie backup Isaac Guerendo scored Niners lone touchdown of night bursting off left side from 15 yards out.

Sunday night was McCaffrey fourth match since returning from Achilles tendinitis that kept him out for most of training camp and all San Francisco first eight matches.

“It was frustrating”Shanahan said

“He had a great week of practice and I could feel his urgency and stuff and thought he came out great looking really good and it looked like he just got his shoestring there I hurt for him and tough for our team not having him”.